GLP-1 weight loss
What are GLP-1s and how do they work?
GLP-1s are medications that mimic the effects of the natural hormone GLP-1, which helps control blood sugar, reduce appetite, and slow stomach emptying. By mimicking these effects, GLP-1s can help people with type 2 diabetes better manage their blood sugar levels and, for some, achieve weight loss. For obesity, GLP-1s are believed to reduce appetite and increase feelings of fullness, leading to reduced food intake and weight loss.
Tirzepatide
（TR）
Semaglutide
（SM）
MSemaglutide
（SM）
Retatrutide
（RT）
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Semaglutide aids weight loss by mimicking a hormone that regulates appetite, leading to reduced hunger and increased feelings of fullness. It slows gastric emptying, which helps you feel satisfied longer after meals. This combination encourages eating fewer calories without feeling deprived. Additionally, Semaglutide improves insulin sensitivity, supporting better blood sugar management. At Belle Medical, we include Semaglutide in our holistic approach to weight management, helping clients achieve their health and wellness goals more effectively.
Nausea is the number one side effect. Everyone is different, but many people only experience nausea within the first 24-48 hours after the injection. Other side effects may include constipation, diarrhea, nausea, abdominal pain, fatigue, dizziness, or headache.
GLP1 weight loss principle
1. Appetite Suppression and Satiety:
Mimicking GLP-1: These medications mimic the action of the naturally occurring GLP-1 hormone, which is released by the gut in response to food intake.
Brain Signaling: GLP-1 RAs activate GLP-1 receptors in the brain, particularly in areas like the hypothalamus, which are involved in regulating appetite and satiety.
Reduced Hunger and Increased Fullness: This activation leads to a reduced sensation of hunger and increased feelings of fullness, resulting in decreased food intake and calorie consumption.
2. Delayed Gastric Emptying:
Slower Digestion: GLP-1 RAs also slow down the rate at which the stomach empties, which contributes to feeling fuller for longer after eating.
Reduced Blood Sugar Spikes: This slower digestion also helps to control blood sugar levels by reducing the rapid release of glucose from the food into the bloodstream.
3. Metabolic Benefits:
Improved Insulin Function: GLP-1 RAs improve the body’s ability to utilize insulin efficiently, which helps regulate blood sugar and can contribute to weight loss.
Potential Impact on Fat Metabolism: Some studies suggest that GLP-1 RAs may also play a role in promoting healthier fat storage and utilization, further supporting weight loss and overall metabolic health.
4. Potential for Significant Weight Loss:
Clinical Trial Results: Clinical trials have demonstrated that GLP-1 RAs can lead to significant weight loss, with some studies reporting average weight loss of 5% to 15% or even more.
Sustainable Weight Loss: This weight loss has been shown to be sustainable for at least 12 months in some studies.
In essence, GLP-1 RAs facilitate weight loss by influencing the body’s natural processes of appetite regulation, satiety, and metabolism, leading to reduced food intake and improved metabolic function.
It is important to note that while GLP-1 RAs are highly effective for weight management, they should be used in conjunction with healthy lifestyle habits, including a balanced diet and regular exercise, for optimal results.
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